Description and Brand NamesBefore UsingProper UseSide Effects Brand Name : Reopro Descriptions Abciximab is used to lessen the chance of heart attack in people who need percutaneous coronary intervention (PCI), a procedure to open blocked arteries of the heart. A heart attack may occur when a blood vessel in the heart is blocked by a blood clot. Blood clots can sometimes form during PCI. Abciximab reduces the chance that a harmful clot will form by preventing certain cells in the blood from clumping together. Abciximab is used with aspirin and heparin, which are other medicines used to keep your blood from clotting. This medicine is available only with your doctor’s prescription. This product is available in the following dosage forms: Solution In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of abciximab in children with use in other age groups. Geriatric Bleeding problems may be especially likely to occur in elderly patients, who are usually more sensitive than younger adults tot the effects of abciximab. It is important that you discuss the use of this medicine with your doctor. Pregnancy Information about this abciximab-intravenous-route Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breastfeeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Drug Interactions Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Eptifibatide Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Aceclofenac Acemetacin Acenocoumarol Alipogene Tiparvovec Alteplase, Recombinant Amtolmetin Guacil Anagrelide Apixaban Argatroban Aspirin Bivalirudin Bromfenac Bufexamac Celecoxib Choline Salicylate Cilostazol Citalopram Clonixin Dabigatran Etexilate Dalteparin Danaparoid Desirudin Desvenlafaxine Dexibuprofen Dexketoprofen Dextran Diclofenac Diflunisal Dipyridamole Dipyrone Drotrecogin Alfa Duloxetine Enoxaparin Escitalopram Etodolac Etofenamate Etoricoxib Felbinac Fenoprofen Fepradinol Feprazone Floctafenine Flufenamic Acid Fluoxetine Flurbiprofen Fluvoxamine Fondaparinux Heparin Ibuprofen Ibuprofen Lysine Indomethacin Ketoprofen Ketorolac Lepirudin Levomilnacipran Lornoxicam Loxoprofen Lumiracoxib Meclofenamate Mefenamic Acid Meloxicam Milnacipran Morniflumate Nabumetone Naproxen Nefazodone Nepafenac Niflumic Acid Nimesulide Oxaprozin Oxyphenbutazone Parecoxib Paroxetine Phenindione Phenprocoumon Phenylbutazone Piketoprofen Piroxicam Pranoprofen Proglumetacin Propyphenazone Proquazone Protein C, Human Rivaroxaban Rofecoxib Salicylic Acid Salsalate Sertraline Sodium Salicylate Sulindac Tenoxicam Tiaprofenic Acid Ticlopidine Tinzaparin Tolfenamic Acid Tolmetin Valdecoxib Vortioxetine Warfarin Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Vitamin A Other Interactions Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially: Aneurysm (swelling in a blood vessel) especially in the head or Blood disease or a history of unusual bleeding or Brain problems which may include bleeding, disease, injury or tumor or If you weigh less than 150 pounds or If you are over 65 years of age or Injury to any part of the body or Liver disease or Stroke—The risk of bleeding may be increased Also, tell your doctor if you have received abciximab or heparin before and had a reaction to either of them called thrombocytopenia (a low platelet count in the blood), or if new blood clots formed while you were receiving the medicine. In addition, tell your doctor if you have recently had any bleeding from the stomach, previously had a stroke, recently fallen or suffered a blow to the body or head, or had major medical or dental surgery . These events may increase the risk of serious bleeding when you are taking abciximab. The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For injection dosage form: For prevention of blood clots during percutaneous coronary intervention (the procedure to open blocked blood vessels): Adults—Initial dose: 250 micrograms (mcg) per kilogram (kg) of body weight injected 10 to 60 minutes before the procedure. Maintenance dose: 0.125 mcg per kg of body weight per minute (maximum of 10 mcg per minute) by IV for 12 hours. Children—Use and dose must be determined by your doctor. For patients with unstable angina that will undergo percutaneous coronary intervention within 24 hours: Adults—Initial dose: 250 micrograms (mcg) per kilogram (kg) of body weight injected. Maintenance dose: 10 mcg per minute by IV for 18 to 24 hours, ending 1 hour after the procedure. Children—Use and dose must be determined by your doctor. Tell all of your medical doctors and dentists that you are using this medicine. Check with your doctor immediately if you notice any of the following side effects: Bruising or bleeding, especially bleeding that is hard to stop. Bleeding inside the body sometimes appears as bloody or black, tarry stools, or faintness. Back pain; burning, pricking, tickling, or tingling sensation; leg weakness; numbness; paralysis; or problems with bowel or bladder function.