Description and Brand NamesBefore UsingProper UsePrecautionsSide Effects Brand Name : Dantrium Intravenous Revonto Ryanodex Descriptions Dantrolene is used to prevent or treat a medical problem called malignant hyperthermia that may occur in some patients during or following surgery or anesthesia. Malignant hyperthermia consists of a group of symptoms including very high fever, fast and irregular heartbeat, and breathing problems. It is believed that the tendency to develop malignant hyperthermia is inherited. This medicine is available only with your doctor’s prescription. This product is available in the following dosage forms: Powder for Suspension Powder for Solution In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of dantrolene in children. Geriatric Although appropriate studies on the relationship of age to the effects of dantrolene have not been performed in the geriatric patient, no geriatric-specific problems have been documented to date. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution in patients receiving dantrolene. Pregnancy Information about this dantrolene-intravenous-route Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breastfeeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Drug Interactions Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Adinazolam Alfentanil Alprazolam Amlodipine Amobarbital Anileridine Aprobarbital Bromazepam Brotizolam Butabarbital Butalbital Carisoprodol Chloral Hydrate Chlordiazepoxide Chlorzoxazone Cinnarizine Clevidipine Clobazam Clonazepam Clorazepate Codeine Dantrolene Diazepam Diltiazem Estazolam Ethchlorvynol Felodipine Flunitrazepam Flurazepam Halazepam Hydrocodone Hydromorphone Isradipine Ketazolam Levorphanol Lorazepam Lormetazepam Medazepam Meperidine Mephenesin Mephobarbital Meprobamate Metaxalone Methocarbamol Methohexital Methotrexate Midazolam Nicardipine Nifedipine Nimodipine Nisoldipine Nitrazepam Nordazepam Oxazepam Pentobarbital Phenobarbital Prazepam Primidone Propoxyphene Quazepam Remifentanil Secobarbital Sodium Oxybate Sufentanil Temazepam Thiopental Triazolam Verapamil Other Interactions Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given through a needle placed in one of your veins. Your doctor will only give you a few doses of this medicine until your condition improves, and then you will be switched to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor. This medicine may cause drowsiness, dizziness, or muscle weakness in some people. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert or well-coordinated. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor or nurse immediately if any of the following side effects occur: Rare Blue lips and fingernails chest pain coughing that sometimes produces a pink frothy sputum difficult, fast, noisy breathing, sometimes with wheezing difficulty swallowing dizziness fast heartbeat hives increased sweating itching pale skin puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue shortness of breath skin rash swelling in legs and ankles tightness in chest tissue necrosis unusual tiredness or weakness wheezing Incidence not known Changes in skin color, pain, tenderness, or swelling of foot or leg Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Rare Flushing or redness of skin unusually warm skin Incidence not known Drowsiness muscle weakness Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.